Home  |  Login  |  Inquiries | TOC Alerts  |  Sitemap |  

Advanced Search
J Exerc Rehabil > Volume 14(3);2018 > Article
Kim, Kim, Kim, Yoon, and Chung: Urology as rehabilitation medicine: a literature review

Abstract

As a urologist, we usually encounter with two representative functional behaviors, namely, voiding and sexual function. These are not only important but also complex and synchronized so if these functions are impaired, patients need active functional rehabilitation to recover. These functional impairments should be recognized and corrected early because they could not only cause direct damage to the affected functions but also have harmful consecutive consequences such as kidney damage due to voiding abnormality and self-esteem damage due to decreased sexual function. Numerous rehabilitative methods are currently available, which help minimize the negative effects of these functional impairments. In terms of voiding function, pelvic floor muscle exercise, biofeedback, functional magnetic stimulation, neuromodulation, and clean intermittent self-catheterization are representative rehabilitation modalities. In case of children, extra-attention should be paid because this might affect their entire life. In impairment of sexual function, early intervention to maintain male erection is the main target of rehabilitation to prevent corporal fibrosis and penile deformity and increase recovery chance in patients who underwent radical prostatectomy or major surgery. In this review, we will elucidate various rehabilitation methods in urology to further increase our understanding of the rehabilitative characteristics of urology and widen our view of rehabilitation medicine.

INTRODUCTION

Urology is often characterized that has both medical and surgical nature. However, there is another unique characteristic of urology that people do not know well, that is physical medicine, so, it could be considered a type of rehabilitative medicine. In order to see urologic field as a perspective of rehabilitation, it should have functional impairment and that can be recovered or restored after active intervention of professionals. In urology, voiding difficulty and sexual dysfunctions are representatives of such functional impairments. These two are very important functional behaviors, and both of which have unique characteristic that they are partly involuntary and partly voluntary behaviors.
Voiding is a natural and unconsciously performed behavior. However, normal voiding requires a synchronized sequence of complex muscle movement and control. Impairment of normal voiding function not only causes single voiding difficulty but also affects all subsequent voiding, impairs kidney function, and ultimately affects the quality of life (QoL) (Choi and Bae, 2016). Therefore, it is very important to normalize or, at least, minimize the negative effects of voiding abnormality to the patients who have distorted voiding mechanism.
Voiding abnormality in children has additional importance because of their young age. Children should establish the basics of a healthy urination mechanism and abnormal voiding behavior happens repeatedly during their whole life (Costantini et al., 2018). Therefore, when we treat pediatric patients with voiding abnormality, more attention should be paid in addition to consideration of the general abnormal voiding aspects. Furthermore, children are very vulnerable, in that abnormal voiding might affect not only their personality but also their psychosocial aspect (Costantini et al., 2018).
Sexual function is a complex behavior that is influenced by psychological and physical factors, and it affects not only the QoL of individuals but also their interpersonal relationship of couple or family (Eton and Lepore, 2002). In sexual function, it has both masculine and feminine aspects, but given the paucity of studies on and poor knowledge about female sexuality, sexual rehabilitation usually refers to male sexual dysfunction, also known as erectile dysfunction (ED). In particular, the concept of sexual rehabilitation is usually applicable in cases of ED cause by nerve injury after spinal trauma and major surgery, such as radical prostatectomy (RP) (Eton and Lepore, 2002; Walsh and Schlegel, 1988). Penile rehabilitation was devised from the theory that early penile circulation might help recovery and prevent corporeal fibrosis and penile contracture (Briganti and Montorsi, 2006).
At present, many urologic approaches have been developed and performed to restore or preserve voiding and sexual functions. In this review, we will introduce the rehabilitative aspect of urology and review various rehabilitation methods. We expect that may contribute to the expanding view of rehabilitation experts and may have any type of chance to cooperate between rehabilitation and urology field.

BLADDER REHABILITATION

The urinary bladder is the major organ of urology; hence, various bladder rehabilitation methods for diverse functional abnormal status affecting the bladder are being performed. Not only the major disease state such as stress urinary incontinence (SUI), overactive bladder (OAB), neurogenic bladder (NB), but also the abnormal voiding status after RP, and orthotopic neobladder (ONB) after radical cystectomy are representative status of the bladder that needs rehabilitation. For these disease states, pelvic floor muscle exercise (PFE), bladder training, functional magnetic stimulation (FMS), electrical neuromodulation, and clean intermittent self-catheterization (CIC) can be employed as rehabilitation methods (Olujide and O’Sullivan, 2005) (Fig. 1).
PFE, first described by Kegel, is the exercise that was thought to strengthen the pelvic floor muscle to further support the urethra (Dumoulin et al., 2014). In this technique, patients are trained to consciously contract their pelvic floor muscles to prevent SUI, and, when there is increasing abdominal pressure or pelvic muscle spasm, it helps relaxation of such muscles particularly in OAB or urge incontinence (Dumoulin et al., 2014). Moreover, concomitant biofeedback could synergistically reinforce the PFE (Newman, 2014).
Bladder retraining might be helpful to treat OAB with or without urge incontinence by gradual and continuous elongation of urination interval in timed voiding (Wein, 2005). FMS has been adopted as a form of physical therapy for OAB (But, 2003). Since the Food and Drug Administration approved magnetic stimulation for urinary incontinence in 1998, electrical muscle stimulation was performed as a short-term treatment for urinary incontinence (Lim et al., 2015). It can be performed with ease in patients: they only sit on the magnetic chair without experiencing any pain.
Electrical neuromodulation may ameliorate lower urinary tract dysfunction ranging from OAB, urge incontinence to interstitial cystitis (Abello and Das, 2018). Although surgical intervention is needed for the placement of a low-amplitude electrical stimulator, programmable adjustments in office-based techniques to afford optimized rates based on the severity of symptoms are also required (Marcelissen et al., 2010). Sacral nerve stimulation or percutaneous tibial nerve stimulation could be performed according to the stimulation level (Marcelissen et al., 2010; Sajadi and Goldman, 2010).
In case of SUI after RP, PFE may improve early continence and QoL after PR (Goonewardene et al., 2018). Furthermore, ONB, wherein a bladder is artificially constructed using various parts of the bowel following radical cystectomy for bladder cancer, is the most extreme urologic condition that requires bladder rehabilitation. The patients should be trained to urination with abdominal pressure right after the surgery performed (Steers, 2000). In ONB, various bladders functional abnormalities such as SUI, nocturnal enuresis (NE), and urinary retention might be experienced (Steers, 2000). Injection of debulking agent or artificial urethral sphincter, an alarm clock in frequent awakening for timed voiding, and CIC are the most effective management methods for SUI, NE, and urinary retention, respectively (Steers, 2000).

BLADDER REHABILITATION IN CHILDREN

In addition to general voiding dysfunction mentioned above, numerous abnormalities should be considered in children, such as NE and other dysfunctional voiding (Fig. 1).
NE is most common voiding abnormality in children that is the voluntary or involuntary wetting with urine and has significant psychological effects on both child and the family (Arda et al., 2016). Bedwetting alarm is a representative therapy for the children with NE. The NE patients should put the alarm device with humidity sensor in their underwear. The bedwetting alarm works by detecting urine; hence, it makes the child hold their urination (Robertson et al., 2014). It also shows a synergic effect when used with drug therapy (Robertson et al., 2014). Positive reinforcement using bedwetting chart or diary with reward system for dry night may also motivate the child, and with these methods, up to 70% of patients with NE showed definite improvement (Marshall et al., 1973). FMS is proposed as a potent treatment in children with NE under the possible mechanism of cortical arousal (But and Varda, 2006).
Dysfunctional voiding is a type of coordination failure of the detrusor (or pelvic floor muscle) and external sphincter without neuroanatomical abnormality that usually causes lower urinary tract symptom, urinary incontinence, vesicoureteral reflux, and kidney function damage (Glassberg et al., 2010). In other words, affected patients habitually contract their urethral sphincter during voiding, hence it is important to correct toilet habit and posture (Clothier and Wright, 2018). The appropriate posture is to sit securely with comfortable hip abduction that does not stimulate the pelvic floor muscles (Glassberg et al., 2010). Trunk core muscle including pelvic floor relaxation could be attained with full stabilization by supported sitting and relaxed abdominal wall. Neutral lumbar spine position and slightly abducted feet also help attain pelvic floor relaxation (Wennergren et al., 1991). Bladder training, biofeedback, and PFE are appropriate management methods of treating patients with dysfunctional voiding. This method is a form of retraining for normally unconscious physiological process by transition to direct tangible signals. This process is transformed to the signal which may be expressed by monitor or speaker, help restore and facilitate habituation of the normal urination mechanism (Clothier and Wright, 2018).

PENILE REHABILITATION

Given the increasing incidence of prostate cancer, ED after RP is also increased (Köhler et al., 2014). RP is the leading cause of ED after a medical procedure and may cause long-term psychological and functional dysfunction (Köhler et al., 2014). Other urologic and radical surgeries, such as prostatectomy, also increase the incidence of ED (Chung and Woo, 2016; De Luca et al., 1996).
In penile rehabilitation, early and recurrent initiations of erections might accelerate local blood circulation to the penis in order to prevent corporal hypoxia and subsequent cavernosal fibrosis and to facilitate vascular and neural recovery (Carrier et al., 1995; Cui et al., 2017; Iacono et al., 2008; Mulhall et al., 2010). Furthermore, current rehabilitation uses traditional methods to treat ED, such as phosphodiesterase type 5 inhibitor (PDE5i) medication (Brock et al., 2003), intracavernosal (IC) injection therapy (Montorsi et al., 1997), intraurethral alprostdil (Hatzimouratidis et al., 2016), and vacuum erection device (Raina et al., 2006) (Fig. 2). In addition, PFE was also reported to improve ED after RP (Goonewardene et al., 2018).
Oral PDE5i medication therapy is a very convenient method, and diverse medications with similar mechanism of action were developed. While most rehabilitation modalities are used by on-demand basis only, PDE5i has unique characteristics: it can be used for both on-demand and persistent usage (Montorsi et al., 2008). Self-injection to one’s own penis (IC injection) is a quite effective but difficult method to employ because it is hard to learn and troublesome to perform (Belew et al., 2015). Complications such as pain, hematoma, priapism, and penile fibrosis are one of the problems with IC therapy (Belew et al., 2015). Intraurethral alprostadil is a noninvasive self-applying method before intercourse, which is known that is easy to learn and safe but has relatively low efficacy (Hatzimouratidis et al., 2016) (Fig. 2). Unlike IC injection therapy, which has that risk, vacuum device is very safe and easy method to apply (Iacono et al., 2008). The device generates negative pressure and induces congestion in the penis to cause erection. Its disadvantage is the operability of the device, and it colds the penis, but it attains a good erection function (Engel, 2011).
Although some controversy exists on whether penile rehabilitation can improve the recovery of spontaneous erection, these methods are confirmed to enhance erectile function during treatment (Liu et al., 2017). Therefore, many urologists continue to recommend and prescribe some of these penile rehabilitation methods after surgery.

Notes

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

REFERENCES

Abello A, Das AK. Electrical neuromodulation in the management of lower urinary tract dysfunction: evidence, experience and future prospects. Ther Adv Urol. 2018;10:165–173.
crossref pmid pmc

Arda E, Cakiroglu B, Thomas DT. Primary nocturnal enuresis: a review. Nephrourol Mon. 2016;8:e35809
crossref pmid pmc

Belew D, Klaassen Z, Lewis RW. Intracavernosal Injection for the diagnosis, evaluation, and treatment of erectile dysfunction: a review. Sex Med Rev. 2015;3:11–23.
crossref pmid

Briganti A, Montorsi F. Penile rehabilitation after radical prostatectomy. Nat Clin Pract Urol. 2006;3:400–401.
crossref pmid pdf

Brock G, Nehra A, Lipshultz LI, Karlin GS, Gleave M, Seger M, Padma-Nathan H. Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy. J Urol. 2003;170:4 Pt 1. 1278–1283.
crossref pmid

But I. Conservative treatment of female urinary incontinence with functional magnetic stimulation. Urology. 2003;61:558–561.
crossref pmid

But I, Varda NM. Functional magnetic stimulation: a new method for the treatment of girls with primary nocturnal enuresis? J Pediatr Urol. 2006;2:415–418.
crossref pmid

Carrier S, Hricak H, Lee SS, Baba K, Morgan DM, Nunes L, Ross GY, Phillips TL, Lue TF. Radiation-induced decrease in nitric oxide synthase--containing nerves in the rat penis. Radiology. 1995;195:95–99.
crossref pmid

Choi H, Bae JH. Overview of the epidemiology of lower urinary tract dysfunction in South Korea. Int Neurourol J. 2016;20:91–100.
crossref pmid pmc pdf

Chung A, Woo HH. Preservation of sexual function when relieving benign prostatic obstruction surgically: can a trade-off be considered? Curr Opin Urol. 2016;26:42–48.
crossref pmid

Clothier JC, Wright AJ. Dysfunctional voiding: the importance of non-invasive urodynamics in diagnosis and treatment. Pediatr Nephrol. 2018;33:381–394.
crossref pmid pdf

Costantini E, Illiano E, Giannitsas K, Prestipino M, Pastore AL, Carbone A, Palleschi G, Balsamo R, Natale F, Villari D, Bini V, Maruccia S, Filocamo MT, Zucchi A. Urological dysfunction in young women: an inheritance of childhood? BJU Int. 2018;121:453–457.
crossref pmid

Cui K, Luan Y, Wang T, Zhuan L, Rao K, Wang SG, Ye ZQ, Liu JH, Wang DW. Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase/LIM-kinase/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1. Asian J Androl. 2017;19:67–72.
crossref pmid

De Luca V, Pescatori ES, Taher B, Zambolin T, Giambroni L, Frego E, Cosciani Cunico S. Damage to the erectile function following radical pelvic surgery: prevalence of veno-occlusive dysfunction. Eur Urol. 1996;29:36–40.
crossref pmid

Dumoulin C, Hay-Smith EJ, Mac Habée-Séguin G. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2014;5. CD005654


Engel JD. Effect on sexual function of a vacuum erection device post-prostatectomy. Can J Urol. 2011;18:5721–5725.
pmid

Eton DT, Lepore SJ. Prostate cancer and health-related quality of life: a review of the literature. Psychooncology. 2002;11:307–326.
crossref pmid pmc

Glassberg KI, Combs AJ, Horowitz M. Nonneurogenic voiding disorders in children and adolescents: clinical and videourodynamic findings in 4 specific conditions. J Urol. 2010;184:2123–2127.
crossref pmid

Goonewardene SS, Gillatt D, Persad R. A systematic review of PFE pre-prostatectomy. J Robot Surg. 2018. Mar. 21. [Epub]. https://doi.org/10.1007/s11701-018-0803-8 .
crossref pdf

Hatzimouratidis K, Salonia A, Adaikan G, Buvat J, Carrier S, El-Meliegy A, McCullough A, Torres LO, Khera M. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016;13:465–488.
crossref pmid

Iacono F, Prezioso D, Somma P, Chierchia S, Galasso R, Micheli P. Histopathologically proven prevention of post-prostatectomy cavernosal fibrosis with sildenafil. Urol Int. 2008;80:249–252.
crossref pmid

Köhler N, Friedrich M, Gansera L, Holze S, Thiel R, Roth S, Rebmann U, Stolzenburg JU, Truss MC, Fahlenkamp D, Scholz HJ, Brähler E. Psychological distress and adjustment to disease in patients before and after radical prostatectomy. Results of a prospective multi-centre study. Eur J Cancer Care (Engl). 2014;23:795–802.
crossref pmid

Lim R, Lee SW, Tan PY, Liong ML, Yuen KH. Efficacy of electromagnetic therapy for urinary incontinence: a systematic review. Neurourol Urodyn. 2015;34:713–722.
crossref pmid

Liu C, Lopez DS, Chen M, Wang R. Penile rehabilitation therapy following radical prostatectomy: a meta-analysis. J Sex Med. 2017;14:1496–1503.
crossref pmid

Marcelissen TA, Leong RK, de Bie RA, van Kerrebroeck PE, de Wachter SG. Long-term results of sacral neuromodulation with the tined lead procedure. J Urol. 2010;184:1997–2000.
crossref pmid

Marshall S, Marshall HH, Lyon RP. Enuresis: an analysis of various therapeutic approaches. Pediatrics. 1973;52:813–817.
pmid

Montorsi F, Brock G, Lee J, Shapiro J, Van Poppel H, Graefen M, Stief C. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol. 2008;54:924–931.
crossref pmid

Montorsi F, Guazzoni G, Strambi LF, Da Pozzo LF, Nava L, Barbieri L, Rigatti P, Pizzini G, Miani A. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol. 1997;158:1408–1410.
crossref pmid

Mulhall JP, Bella AJ, Briganti A, McCullough A, Brock G. Erectile function rehabilitation in the radical prostatectomy patient. J Sex Med. 2010;7:4 Pt 2. 1687–1698.
crossref pmid

Newman DK. Pelvic floor muscle rehabilitation using biofeedback. Urol Nurs. 2014;34:193–202.
pmid

Olujide LO, O’Sullivan SM. Female voiding dysfunction. Best Pract Res Clin Obstet Gynaecol. 2005;19:807–828.
crossref pmid

Raina R, Agarwal A, Ausmundson S, Lakin M, Nandipati KC, Montague DK, Mansour D, Zippe CD. Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res. 2006;18:77–81.
crossref pmid pdf

Robertson B, Yap K, Schuster S. Effectiveness of an alarm intervention with overlearning for primary nocturnal enuresis. J Pediatr Urol. 2014;10:241–245.
crossref pmid

Sajadi KP, Goldman HB. Percutaneous tibial nerve stimulation and overactive bladder. Curr Urol Rep. 2010;11:293–295.
crossref pmid

Steers WD. Voiding dysfunction in the orthotopic neobladder. World J Urol. 2000;18:330–337.
crossref pmid

Walsh PC, Schlegel PN. Radical pelvic surgery with preservation of sexual function. Ann Surg. 1988;208:391–400.
crossref pmid pmc

Wein AJ. Bladder training for urinary incontinence in adults. J Urol. 2005;173:1263–1264.
crossref pmid

Wennergren HM, Oberg BE, Sandstedt P. The importance of leg support for relaxation of the pelvic floor muscles. A surface electromyograph study in healthy girls. Scand J Urol Nephrol. 1991;25:205–213.
crossref pmid

Fig. 1
Voiding dysfunction and its rehabilitation modality: schematic view. PFE, pelvic floor exercise; BF, bio-feedback; FMS, functional magnetic stimulation; BT, bladder training; NM, neuromodulation; CIC, clean intermittent catheterization.
/upload/thumbnails/jer-14-3-322f1.gif
Fig. 2
Penile rehabilitation modality.
/upload/thumbnails/jer-14-3-322f2.gif

Editorial Office
11th Floor, Gachon University Gil Hospital, 1198, Guwol-dong, Namdong-Gu, 405-760, Incheon, Korea
TEL: +82-32-460-3334   FAX: +82-32-460-8340   E-mail: journal@kser.co.kr
Copyright © Korean Society of Exercise Rehabilitation. All rights reserved.