JER :: Journal of Exercise Rehabilitation

Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets

Yi Luan, Xiaofan Zhu, Yuxue Jiao, Hui Liu, Zhen Huang, Jinyan Pei, Yawei Xu, Yang Yang, Kaidi Ren

Microphysiological systems for human aging research

Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok‐Ho Kim

Nadia Chandra Sekar, Khashayar Khoshmanesh, Sara Baratchi

3D printed scaffolds of biosilica and spongin from marine sponges: analysis of genotoxicity and cytotoxicity for bone tissue repair

Karolyne dos Santos Jorge Sousa, Amanda de Souza, Matheus de Almeida Cruz, Lindiane Eloisa de Lima, Giovanna do Espirito Santo, Gustavo Oliva Amaral, Renata Neves Granito, Ana Claudia Renno

Bioprocess and Biosystems Engineering.2024; 47(9): 1483. CrossRef

Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9

Kaichuan He, Huaxing Zhang, Bo Tan, Chengqing Song, Zihui Liang, Lixia Zhang, Danyang Tian, Lin Xiao, Hongmei Xue, Qi Guo, Xu Teng, Sheng Jin, Cuixia An, Yuming Wu

Cardiovascular Drugs and Therapy.2024;[Epub] CrossRef

The Interplay between Mechanoregulation and ROS in Heart Physiology, Disease, and Regeneration

Arturo Elias‐Llumbet, Rokshana Sharmin, Kirstine Berg‐Sorensen, Romana Schirhagl, Aldona Mzyk

Identification of senescence related hub genes and potential therapeutic compounds for dilated cardiomyopathy via comprehensive transcriptome analysis

Chong Du, Sibo Wang, Xinying Shi, Peng Jing, Hao Wang, Liansheng Wang

Computers in Biology and Medicine.2024; 179: 108901. CrossRef

Effect of Ageing Process on Diastolic Function of the Heart

Journal of Prevention, Diagnosis and Management of Human Diseases.2024; (45): 18. CrossRef

MircroRNA-145 Attenuates Cardiac Fibrosis Via Regulating Mitogen-Activated Protein Kinase Kinase Kinase 3

Cardiovascular Drugs and Therapy.2023; 37(4): 655. CrossRef

The Involvement of Krüppel-like Factors in Cardiovascular Diseases

Michelle G. Santoyo-Suarez, Jimena D. Mares-Montemayor, Gerardo R. Padilla-Rivas, Juan Luis Delgado-Gallegos, Adriana G. Quiroz-Reyes, Jorge A. Roacho-Perez, Diego F. Benitez-Chao, Lourdes Garza-Ocañas, Gilberto Arevalo-Martinez, Elsa N. Garza-Treviño, Jo

Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research

Leena Patel, Joshua C. Worch, Andrew P. Dove, Katja Gehmlich

International Journal of Molecular Sciences.2023; 24(12): 9995. CrossRef

Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation

Carolina Tocantins, João D. Martins, Óscar M. Rodrigues, Luís F. Grilo, Mariana S. Diniz, Jelena Stevanovic‐Silva, Jorge Beleza, Pedro Coxito, David Rizo‐Roca, Estela Santos‐Alves, Manoel Rios, Lina Carvalho, António J. Moreno, António Ascensão, José Maga

European Journal of Clinical Investigation.2023;[Epub] CrossRef

SGLT2 Inhibitors in Aging-Related Cardiovascular Disease: A Review of Potential Mechanisms

Yali Zhang, Yufeng He, Siqi Liu, Li Deng, Yumei Zuo, Keming Huang, Bin Liao, Guang Li, Jian Feng

American Journal of Cardiovascular Drugs.2023; 23(6): 641. CrossRef

Role of TGF-β and p38 MAPK in TSG-6 Expression in Adipose Tissue-Derived Stem Cells In Vitro and In Vivo

Hye Youn Kwon, Yongdae Yoon, Ju-Eun Hong, Ki-Jong Rhee, Joon Hyung Sohn, Pil Young Jung, Moon Young Kim, Soon Koo Baik, Hoon Ryu, Young Woo Eom

International Journal of Molecular Sciences.2023; 25(1): 477. CrossRef

Relationship of collagen as the component of the extracellular matrix with the mechanisms of autonomic regulation of the cardiovascular system under simulated conditions of long-term isolation

V.B. Rusanov, L. Kh. Pastushkova, A.G. Chernikova, D.N. Kashirina, A.G. Goncharova, A.M. Nosovsky, A.R. Kussmaul, Y.D. Yakhya, O.V. Popova, A.G. Brzhozovskiy, O.I. Orlov, I.M. Larina

Life Sciences in Space Research.2022; 32: 17. CrossRef

Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis

Ghulam Shere Raza, Nalini Sodum, Yagmur Kaya, Karl-Heinz Herzig

International Journal of Molecular Sciences.2022; 23(21): 12954. CrossRef

Effects of Tai Chi Chuan on the Physical and Mental Health of the Elderly: A Systematic Review

Physical Activity and Health.2021; 5(1): 21. CrossRef

Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age‐Related Oxidative Stress and Cardiac Remodeling

Renáta Szabó, Alexandra Hoffmann, Denise Börzsei, Krisztina Kupai, Médea Veszelka, Anikó Magyariné Berkó, Imre Pávó, Rudolf Gesztelyi, Béla Juhász, Zsolt Turcsán, Anikó Pósa, Csaba Varga, Claudio Cabello-Verrugio

Oxidative Medicine and Cellular Longevity.2021;[Epub] CrossRef

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

Ana Santos, Yongjun Jang, Inwoo Son, Jongseong Kim, Yongdoo Park

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Fibrosis as a result of polyhexamethylene guanide exposure in cultured Statens Seruminstitut Rabbit Cornea (SIRC) cells

Environmental Analysis Health and Toxicology.2021; 36(2): e2021009. CrossRef

Physical exercise prevents age-related heart dysfunction induced by high-salt intake and heart salt-specific overexpression in Drosophila

Elastin Structure, Synthesis, Regulatory Mechanism and Relationship With Cardiovascular Diseases

Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef

Cardiac adaptation to exercise training in health and disease

Dae Yun Seo, Hyo-Bum Kwak, Amy Hyein Kim, Se Hwan Park, Jun Won Heo, Hyoung Kyu Kim, Jeong Rim Ko, Sam Jun Lee, Hyun Seok Bang, Jun Woo Sim, Min Kim, Jin Han

Pflügers Archiv - European Journal of Physiology.2020; 472(2): 155. CrossRef

Severe elastolysis in hereditary gelsolin (AGel) amyloidosis

Susanna Koskelainen, Fang Zhao, Hannu Kalimo, Marc Baumann, Sari Kiuru-Enari

A 6-month systems toxicology inhalation study in ApoE−/− mice demonstrates reduced cardiovascular effects of E-vapor aerosols compared with cigarette smoke

Justyna Szostak, Ee Tsin Wong, Bjoern Titz, Tom Lee, Sin Kei Wong, Tiffany Low, Kyeonghee Monica Lee, Jingjie Zhang, Ashutosh Kumar, Walter K. Schlage, Emmanuel Guedj, Blaine Phillips, Patrice Leroy, Ansgar Buettner, Yang Xiang, Florian Martin, Alain Sewe

American Journal of Physiology-Heart and Circulatory Physiology.2020; 318(3): H604. CrossRef

Cardiac-specific inactivation of Prdm16 effects cardiac conduction abnormalities and cardiomyopathy-associated phenotypes

Jeong Min Nam, Ji Eun Lim, Tae Woong Ha, Bermseok Oh, Ji-One Kang

American Journal of Physiology-Heart and Circulatory Physiology.2020; 318(4): H764. CrossRef

Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging

Cell Transplantation.2020; 29: 096368972092083. CrossRef

Robust Fabrication of Composite 3D Scaffolds with Tissue-Specific Bioactivity: A Proof-of-Concept Study

Muthu Kumar Krishnamoorthi, Udi Sarig, Limor Baruch, Sherwin Ting, Shaul Reuveny, Steve Oh, Idit Goldfracht, Lior Gepstein, Subramanian S. Venkatraman, Lay Poh Tan, Marcelle Machluf

ACS Applied Bio Materials.2020; 3(8): 4974. CrossRef

Exercise improves cardiac function and glucose metabolism in mice with experimental myocardial infarction through inhibiting HDAC4 and upregulating GLUT1 expression

Hao Jiang, Daile Jia, Beijian Zhang, Wenlong Yang, Zhen Dong, Xiaolei Sun, Xiaotong Cui, Leilei Ma, Jian Wu, Kai Hu, Aijun Sun, Junbo Ge

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells

Da Hyeon Choi, Se-Young Oh, Ju Kwang Choi, Kyeong Eun Lee, Ju Yeon Lee, Yoon Jeong Park, Inho Jo, Yoon Shin Park

Morphofunctional features of the cardiovascular system in extreme specialists of the navy (depending on the polymorphism of the genes of the matrix metalloprotheinase 1 (MMP-1) and collagen 1 (COL1A1)

A. N. Nikashin, D. V. Cherkashin, V. P. Andrianov, A. Ja. Fisun

Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction

Hui Yang, Yuhu He, Pu Zou, Yilei Hu, Xuping Li, Liang Tang, Zhaowei Zhu, Shi Tai, Tao Tu, Yichao Xiao, Mingxian Chen, Chenlu Wu, Shenghua Zhou

Pathophysiology, Clinical Characteristics of Diabetic Cardiomyopathy: Therapeutic Potential of Natural Polyphenols

Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes

Signe Holm Nielsen, Alan J. Mouton, Kristine Y. DeLeon-Pennell, Federica Genovese, Morten Karsdal, Merry L. Lindsey

Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

Saudi Journal of Biological Sciences.2019; 26(5): 950. CrossRef

Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly

Pharmacology & Therapeutics.2019; 193: 99. CrossRef

Incorporation of Collagen from Marine Sponges (Spongin) into Hydroxyapatite Samples: Characterization and In Vitro Biological Evaluation

J. R. Parisi, K. R. Fernandes, I. R. Avanzi, B. P. Dorileo, A. F. Santana, A. L. Andrade, P. R. Gabbai-Armelin, C. A. Fortulan, E. S. Trichês, R. N. Granito, A. C. M. Renno

Effect of Tai Chi on Cardiac and Static Pulmonary Function in Older Community-Dwelling Adults at Risk of Ischemic Stroke: A Randomized Controlled Trial

Guo-hua Zheng, Xin Zheng, Jun-zhe Li, Ting-jin Duan, Jing Tao, Li-dian Chen

Chinese Journal of Integrative Medicine.2019; 25(8): 582. CrossRef

Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

Changes in Titin and Collagen Modulate Effects of Aerobic and Resistance Exercise on Diabetic Cardiac Function

Shunchang Li, Min Liang, Derun Gao, Quansheng Su, Ismail Laher

Journal of Cardiovascular Translational Research.2019;[Epub] CrossRef

Novel role of extracellular matrix protein 1 (ECM1) in cardiac aging and myocardial infarction

Sean A. Hardy, Nishani S. Mabotuwana, Lucy A. Murtha, Brianna Coulter, Sonia Sanchez-Bezanilla, Mohammed S. Al-Omary, Tharindu Senanayake, Svenja Loering, Malcolm Starkey, Randall J. Lee, Peter P. Rainer, Philip M. Hansbro, Andrew J. Boyle, Dinender K. Si

3D Structure and Processing Methods Direct the Biological Attributes of ECM-Based Cardiac Scaffolds

Yael Efraim, Beth Schoen, Sharbel Zahran, Tzila Davidov, Gleb Vasilyev, Limor Baruch, Eyal Zussman, Marcelle Machluf

Effects of bio-inspired bioglass/collagen/magnesium composites on bone repair

Paulo Roberto Gabbai-Armelin, Hueliton Wilian Kido, Kelly Rossetti Fernandes, Carlos Alberto Fortulan, Ana Claudia Muniz Renno

Journal of Biomaterials Applications.2019; 34(2): 261. CrossRef

Plasma matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs and aging and lifelong exercise adaptations in ventricular and arterial stiffness

Graeme Carrick-Ranson, Francis G. Spinale, Paul S. Bhella, Satyam Sarma, Shigeki Shibata, Naoki Fujimoto, Jeffrey L. Hastings, Benjamin D. Levine

The role of FHL2 in wound healing and inflammation

Extracellular Matrix in Regulation of Contractile System in Cardiomyocytes

International Journal of Molecular Sciences.2019; 20(20): 5054. CrossRef

Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart

Dan Liu, Linguo Wu, Ye Wu, Xin Wei, Wen Wang, Suli Zhang, Ming Yi, Jing Li, Huirong Liu, Xinliang Ma

Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts

Bianca C. Bernardo, Jenny Y. Y. Ooi, Kate L. Weeks, Natalie L. Patterson, Julie R. McMullen

Estrés oxidativo mitocondrial y envejecimiento cardíaco

Clínica e Investigación en Arteriosclerosis.2018; 30(2): 74. CrossRef

Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease

Swati Naphade, Alexander Embusch, Kuruwitage Lakshika Madushani, Karen L. Ring, Lisa M. Ellerby

Role of Exercise‐Induced Cardiac Remodeling in Ovariectomized Female Rats

Renáta Szabó, Zoltán Karácsonyi, Denise Börzsei, Béla Juhász, Amin Al-awar, Szilvia Török, Anikó Magyariné Berkó, István Takács, Krisztina Kupai, Csaba Varga, Anikó Pósa, Undurti N. Das

Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef

Imaging technologies for cardiac fiber and heart failure: a review

Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart

Natasha Whitehead, Jonathan F. Gill, Marijke Brink, Christoph Handschin

Platycodin D Reverses Pathological Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats

Yuan-Chuan Lin, Yu-Chen Lin, Wei-Wen Kuo, Chia-Yao Shen, Yi-Chang Cheng, Yueh-Min Lin, Ruey-Lin Chang, Vijaya V. Padma, Chih-Yang Huang, Chih-Yang Huang

The American Journal of Chinese Medicine.2018; 46(03): 537. CrossRef

Mitochondrial oxidative stress and cardiac ageing

Clínica e Investigación en Arteriosclerosis (English Edition).2018; 30(2): 74. CrossRef

Analysis of Short-Term Smoking Effects in PBMC of Healthy Subjects—Preliminary Study

Joanna Wieczfinska, Tomasz Kowalczyk, Przemyslaw Sitarek, Ewa Skała, Rafal Pawliczak

International Journal of Environmental Research and Public Health.2018; 15(5): 1021. CrossRef

Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research

Vikrant Rai, Poonam Sharma, Swati Agrawal, Devendra K. Agrawal

Molecular and Cellular Biochemistry.2017; 424(1-2): 123. CrossRef

Rejuvenating Strategies for Stem Cell-Based Therapies in Aging

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

Frontiers in Bioengineering and Biotechnology.2017;[Epub] CrossRef

Electrospun Extracellular Matrix: Paving the Way to Tailor‐Made Natural Scaffolds for Cardiac Tissue Regeneration

Beth Schoen, Ron Avrahami, Limor Baruch, Yael Efraim, Idit Goldfracht, Ofek Elul, Tzila Davidov, Lior Gepstein, Eyal Zussman, Marcelle Machluf

Muscle stem cell and physical activity: what point is the debate at?

Gabriele Ceccarelli, Laura Benedetti, Maria Luisa Arcari, Cecilia Carubbi, Daniela Galli

The link between exercise and titin passive stiffness

Experimental Physiology.2017; 102(9): 1055. CrossRef

The Role of Nrf2 in Cardiovascular Function and Disease

Sandro Satta, Ayman M. Mahmoud, Fiona L. Wilkinson, M. Yvonne Alexander, Stephen J. White, Silvana Hrelia

Oxidative Medicine and Cellular Longevity.2017;[Epub] CrossRef

Cardiac fibrosis in the ageing heart: Contributors and mechanisms

Lu Lu, Jingbin Guo, Yue Hua, Kevin Huang, Ruth Magaye, Jake Cornell, Darren J. Kelly, Christopher Reid, Danny Liew, Yingchun Zhou, Aihua Chen, Wei Xiao, Qiang Fu, Bing Hui Wang

Clinical and Experimental Pharmacology and Physiology.2017; 44(S1): 55. CrossRef

Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

Chia-Ying Liu, Susan R. Heckbert, Shenghan Lai, Bharath Ambale-Venkatesh, Mohammad R. Ostovaneh, Robyn L. McClelland, João A.C. Lima, David A. Bluemke

Journal of the American College of Cardiology.2017; 70(25): 3102. CrossRef

Age-Related Dynamics of the Main Extracellular Matrix Components in Residents of the Russian Arctic

L. B. Kim, N. K. Belisheva, A. N. Putyatina, G. S. Russkih, P. M. Kozhin, O. B. Tsypysheva

Extracellular matrix turnover in coronary artery ectasia patients

Ruifeng Liu, Lianfeng Chen, Wei Wu, Houzao Chen, Shuyang Zhang

Matrix metalloproteinase‐9‐dependent mechanisms of reduced contractility and increased stiffness in the aging heart

Rugmani Padmanabhan Iyer, Ying Ann Chiao, Elizabeth R. Flynn, Kevin Hakala, Courtney A. Cates, Susan T. Weintraub, Lisandra E. de Castro Brás

PROTEOMICS – Clinical Applications.2016; 10(1): 92. CrossRef

Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy

Buqing Cao, Qing Yu, Wei Zhao, Zhiping Tang, Binhai Cong, Jiankui Du, Jianqiang Lu, Xiaoyan Zhu, Xin Ni

The expression of CG9940 affects the adaptation of cardiac function, mobility, and lifespan to exercise in aging Drosophila

Deng-tai Wen, Lan Zheng, Liu Ni, Hui Wang, Yue Feng, Min Zhang

Nrf2 signaling and redox homeostasis in the aging heart: A potential target to prevent cardiovascular diseases?

Alejandro Silva-Palacios, Mina Königsberg, Cecilia Zazueta

Effect of Botulinum Toxin Type A on TGF-β/Smad Pathway Signaling: Implications for Silicone-Induced Capsule Formation

Sena Kim, Moonsang Ahn, Yibo Piao, Yooseok Ha, Dae-Kyoung Choi, Min-Hee Yi, Nara Shin, Dong Woon Kim, Sang-Ha Oh

Plastic & Reconstructive Surgery.2016; 138(5): 821e. CrossRef

Incidence and Predictors of Complications During Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation

Emily N. Guhl, Donald Siddoway, Evan Adelstein, Raveen Bazaz, George S. Mendenhall, Jan Nemec, Samir Saba, David Schwartzman, Andrew Voigt, Norman C. Wang, Sandeep K. Jain

Journal of the American Heart Association.2016;[Epub] CrossRef

The Response of Matrix Metalloproteinase-9 and -2 to Exercise

Dahan da Cunha Nascimento, Rita de Cassia Marqueti Durigan, Ramires Alsamir Tibana, João Luiz Quagliotti Durigan, James Wilfred Navalta, Jonato Prestes

Physical exercise and epigenetic adaptations of the cardiovascular system

Cardioprotective Effects of Voluntary Exercise in a Rat Model: Role of Matrix Metalloproteinase-2

Anikó Pósa, Renáta Szabó, Krisztina Kupai, Zoltán Baráth, Zita Szalai, Anett Csonka, Médea Veszelka, Mariann Gyöngyösi, Zsolt Radák, Rudolf Ménesi, Imre Pávó, Anikó Magyariné Berkó, Csaba Varga

Oxidative Medicine and Cellular Longevity.2015; 2015: 1. CrossRef

So! What's aging? Is cardiovascular aging a disease?

Journal of Molecular and Cellular Cardiology.2015; 83: 1. CrossRef

Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis

Guoliang Meng, Jinbiao Zhu, Yujiao Xiao, Zhengrong Huang, Yuqing Zhang, Xin Tang, Liping Xie, Yu Chen, Yongfeng Shao, Albert Ferro, Rui Wang, Philip K. Moore, Yong Ji

Oxidative Medicine and Cellular Longevity.2015; 2015: 1. CrossRef

MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes

Xiaomin Zhang, Gohar Azhar, Emmanuel D. Williams, Steven C. Rogers, Jeanne Y. Wei

BioMed Research International.2015; 2015: 1. CrossRef

Jude M. Phillip, Ivie Aifuwa, Jeremy Walston, Denis Wirtz

Annual Review of Biomedical Engineering.2015; 17(1): 113. CrossRef

Lichan Tao, Yihua Bei, Haifeng Zhang, Junjie Xiao, Xinli Li

Age associated communication between cells and matrix: a potential impact on stem cell-based tissue regeneration strategies

Physical activity diminishes aging-related decline of physical and cognitive performance